White House commits $5 billion to AI science, expanding Genesis Mission to 15 agencies

The White House committed more than $5 billion to expand the Genesis Mission across 15 federal agencies Wednesday, funding 278 AI-for-science projects selected from more than 5,000 applications.

The announcement, made at the first Genesis Mission Summit in Washington, marks the largest response to any funding call in Department of Energy history. The 278 awards span 342 institutions: 16 national laboratories, 142 universities, 157 companies, and 13 nonprofits. Projects cover all 50 states.

"Science: A New Golden Age calls for using AI to supercharge discovery," Michael Kratsios, director of the White House Office of Science and Technology Policy, said in a social media post. "Today we're expanding the White House's Genesis Mission from Energy to a whole-of-government effort."

The participating agencies include the Departments of Health and Human Services, Energy, Transportation, Defense, and Interior. Researchers will use the funding to identify root causes of chronic diseases, accelerate drug discovery, develop longer-lasting construction materials, and improve energy grid reliability.

"The White House is helping bring together all of the different agencies that work on different domains to make them part of this larger effort on AI for science," Kratsios told Reuters.

"America has no shortage of bold ideas or talented scientists, and the response to the Genesis Mission proves that," Energy Secretary Chris Wright said. "The 278 projects selected today represent the very best of our nation's scientific enterprise."

Awardees gain access to the Genesis Mission Platform: DOE supercomputers, advanced AI models through the Transformational AI Models Consortium, agentic AI frameworks, and government datasets on chemicals, critical minerals, and patient health.

The largest single award is a three-year, $60 million nuclear energy project called Prometheus. The project team has raised more than $200 million in industry cost share and $30 million in private capital alongside federal funding. Prometheus will use AI to design, license, manufacture, and operate nuclear reactors.

"The extraordinary response to this RFA demonstrates that America's scientific community is ready to reimagine how discovery happens," Under Secretary for Science Dario Gil said. "We are bringing together the nation's leading researchers, institutions, and technology partners to build the next generation of scientific capability."

Other funded areas include critical mineral extraction, intelligent chip design, commercial fusion energy, quantum computing, and microelectronics manufacturing.

Microsoft committed $40 million in AI computing credits over three years to support the initiative.

The announcement came alongside Kratsios's report to President Trump, "Science: A New Golden Age," which the White House said is the first comprehensive rethinking of the US science enterprise in more than 80 years.

The report calls for shifting roughly $200 billion in annual federal research funding away from universities and toward AI-powered research systems and individual scientists. It argues that federal science funding must be "politically accountable."

Agencies with at least $3 billion in research authority must submit implementation plans within 90 days. The blueprint also identifies national missions including commercial fusion power and returning Americans to the lunar surface by 2028.

The Genesis Mission was established by a November 2025 executive order. The administration said the expansion is the largest marshaling of federal scientific resources since the Apollo program.

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